产品
编 号：F747101
分子式：C18H16O2S
分子量：296.38
分子式：C18H16O2S
分子量：296.38
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
结构图
CAS No: 1799392-31-6
产品详情
生物活性：
CYT296 is a target chromatin de-condensation compound. CYT296 can improve the induction of induced pluripotent stem cell (iPSCs) mediated by defined factors (OSKM) and induce an open chromatin state in Mouse Embryonic Fibroblast (MEFs) to facilitate somatic cell reprogramming. CYT296 can be used for cell replacement therapies and drug screening research.
体内研究：
CYT296 (10-15 4F- and 2F -iPSC clones, 皮下注射, 一次) 在 NOD-SCID 小鼠中生成的 iPSCs 具有多能性。Animal Model:4F- and 2F-iPSC clones mice
Dosage:10-15 4F- and 2F -iPSC clones
Administration:Subcutaneous injection (s.c.)
Result:Obtained 6 out of 10 born mice from clone 4F-1 and 9 out of 15 born mice from clone 2F-1 were chimeras.
体外研究：
CYT296 (250nM, 72小时) 改变 MEFs 染色质，使 Yamanaka 因子更容易接近，并促进重编程过程。CYT296 (250nM, 72小时) 小分子阻断 MEFs 中异染色质组装可以显著改善 iPSC 的生成。
CYT296 is a target chromatin de-condensation compound. CYT296 can improve the induction of induced pluripotent stem cell (iPSCs) mediated by defined factors (OSKM) and induce an open chromatin state in Mouse Embryonic Fibroblast (MEFs) to facilitate somatic cell reprogramming. CYT296 can be used for cell replacement therapies and drug screening research.
体内研究：
CYT296 (10-15 4F- and 2F -iPSC clones, 皮下注射, 一次) 在 NOD-SCID 小鼠中生成的 iPSCs 具有多能性。Animal Model:4F- and 2F-iPSC clones mice
Dosage:10-15 4F- and 2F -iPSC clones
Administration:Subcutaneous injection (s.c.)
Result:Obtained 6 out of 10 born mice from clone 4F-1 and 9 out of 15 born mice from clone 2F-1 were chimeras.
体外研究：
CYT296 (250nM, 72小时) 改变 MEFs 染色质，使 Yamanaka 因子更容易接近，并促进重编程过程。CYT296 (250nM, 72小时) 小分子阻断 MEFs 中异染色质组装可以显著改善 iPSC 的生成。
产品资料
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