产品
编 号：F747096
分子式：C20H19NO4
分子量：337.37
分子式：C20H19NO4
分子量：337.37
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 1798751-25-3
产品详情
生物活性：
GPR40 agonist 6 (Compound 7a) is a potent and selective free fatty acid receptor 1 (FFAR1 or GPR40) agonist with an EC50 of 0.058 μM.
体外研究：
GPR40 agonist 6 (Compound 7a) shows a very favorable ADME profile, and shows no significant inhibition of the principal cytochrome P450 isoforms (1A2, 2C9, 2C19, 2D6 and 3A4) at 5 μM.ADME profile for GPR40 agonist 6 (Compound 7a)GPR40 agonist 6 (Compound 7a)
Plasma protein binding (human)a98.6%
Aqueous solubility (PBS, pH 7.4)b404 μM
Microsomal stability (mouse, t1/2)c434 min
A-B permeability (Caco-2, cm?s-1)d15.2 ? 10-6
aEach value is an average of n = 4, measured at c = 1 μM. bEach value is an average of n = 2. cEach value is an average of n = 5, measured at c = 2 μM. dEach value is an average of n = 2, measured at c = 10 μM.
GPR40 agonist 6 (Compound 7a) is a potent and selective free fatty acid receptor 1 (FFAR1 or GPR40) agonist with an EC50 of 0.058 μM.
体外研究：
GPR40 agonist 6 (Compound 7a) shows a very favorable ADME profile, and shows no significant inhibition of the principal cytochrome P450 isoforms (1A2, 2C9, 2C19, 2D6 and 3A4) at 5 μM.ADME profile for GPR40 agonist 6 (Compound 7a)GPR40 agonist 6 (Compound 7a)
Plasma protein binding (human)a98.6%
Aqueous solubility (PBS, pH 7.4)b404 μM
Microsomal stability (mouse, t1/2)c434 min
A-B permeability (Caco-2, cm?s-1)d15.2 ? 10-6
aEach value is an average of n = 4, measured at c = 1 μM. bEach value is an average of n = 2. cEach value is an average of n = 5, measured at c = 2 μM. dEach value is an average of n = 2, measured at c = 10 μM.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备