产品
编 号：F746943
分子式：C56H91N7O11
分子量：1038.36
分子式：C56H91N7O11
分子量：1038.36
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CAS No: 177586-74-2
产品详情
生物活性：
CAM741 is a selective VCAM-1 translocation inhibitor. CAM741 selectively inhibits VCAM-1 expression by inhibiting its co-translational translocation within the lumen of the endoplasmic reticulum (ER). CAM741 can be used as a molecular tool and can also be used in the research of chronic inflammation and cancer.
体外研究：
CAM741 (5, 10, 50, 100 nM; 24 h) 剂量依赖性地抑制瞬时转染的 HEK-293 细胞中 VCAM1 糖蛋白的表达。CAM741 (10, 33, 100, 333 nM; 24 h) 剂量依赖地抑制 VCAM1 的共翻译易位。CAM741在后靶向步骤抑制 VCAM1 易位，并增强 VCAM1 新生链与 Sec61 β 的相互作用。
CAM741 is a selective VCAM-1 translocation inhibitor. CAM741 selectively inhibits VCAM-1 expression by inhibiting its co-translational translocation within the lumen of the endoplasmic reticulum (ER). CAM741 can be used as a molecular tool and can also be used in the research of chronic inflammation and cancer.
体外研究：
CAM741 (5, 10, 50, 100 nM; 24 h) 剂量依赖性地抑制瞬时转染的 HEK-293 细胞中 VCAM1 糖蛋白的表达。CAM741 (10, 33, 100, 333 nM; 24 h) 剂量依赖地抑制 VCAM1 的共翻译易位。CAM741在后靶向步骤抑制 VCAM1 易位，并增强 VCAM1 新生链与 Sec61 β 的相互作用。
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