产品
编 号：F746896
分子式：C15H26N6O8
分子量：418.4
分子式：C15H26N6O8
分子量：418.4
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CAS No: 175175-23-2
产品详情
生物活性：
Pinealon is a 3-amino acid peptide and shows neuroprotective properties. Pinealon prevents reactive oxygen species (ROS) accumulation and suppresses the activation of ERK 1/2. Pinealon stimulates the functional activity of the main cellular elements of brain tissue, reduces the level of spontaneous cell death. Pinealon protects the rat offspring from prenatal hyperhomocysteinemia.
体内研究：
Pinealon (50, 100, 200 ng/kg; Injection, for 5 days) 对维持大鼠先前获得的技能显示出剂量依赖性作用。Pinealon (10 μg/kg; daily for 5 days) 保护大鼠后代免受产前高同型半胱氨酸血症。Animal Model:200-250 g, white male rats
Dosage:50, 100, 200 ng/kg
Administration: Injection; for 5 days
Result:Showed dose-dependent effects on the maintenance of a previously acquired skill in the Morris maze.
Animal Model:180-200 g, Female Wistar rats
Dosage:10 μg/kg
Administration: I.p.; daily for 5 days
Result:Protected the rat offspring from prenatal hyperhomocysteinemia.
体外研究：
Pinealon (10, 50, 100 nM; 30 min) 以剂量依赖性方式阻止哇巴因诱导的小脑颗粒细胞中 ROS 积累的增加。Pinealon (10 nM; 0, 2.5, 5, 10, 20, 30 min) 抑制暴露于 500 mM 同型半胱氨酸 (HC) 的大鼠小脑颗粒细胞中 ERK 1/2 的激活。
Pinealon is a 3-amino acid peptide and shows neuroprotective properties. Pinealon prevents reactive oxygen species (ROS) accumulation and suppresses the activation of ERK 1/2. Pinealon stimulates the functional activity of the main cellular elements of brain tissue, reduces the level of spontaneous cell death. Pinealon protects the rat offspring from prenatal hyperhomocysteinemia.
体内研究：
Pinealon (50, 100, 200 ng/kg; Injection, for 5 days) 对维持大鼠先前获得的技能显示出剂量依赖性作用。Pinealon (10 μg/kg; daily for 5 days) 保护大鼠后代免受产前高同型半胱氨酸血症。Animal Model:200-250 g, white male rats
Dosage:50, 100, 200 ng/kg
Administration: Injection; for 5 days
Result:Showed dose-dependent effects on the maintenance of a previously acquired skill in the Morris maze.
Animal Model:180-200 g, Female Wistar rats
Dosage:10 μg/kg
Administration: I.p.; daily for 5 days
Result:Protected the rat offspring from prenatal hyperhomocysteinemia.
体外研究：
Pinealon (10, 50, 100 nM; 30 min) 以剂量依赖性方式阻止哇巴因诱导的小脑颗粒细胞中 ROS 积累的增加。Pinealon (10 nM; 0, 2.5, 5, 10, 20, 30 min) 抑制暴露于 500 mM 同型半胱氨酸 (HC) 的大鼠小脑颗粒细胞中 ERK 1/2 的激活。
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