产品
编 号：F746801
分子式：C9H13IN2O6
分子量：372.11
分子式：C9H13IN2O6
分子量：372.11
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CAS No: 17140-71-5
产品详情
生物活性：
Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) hydrate is an iodinated thymidine analogue that competitively inhibits phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase and affecting viral replication. Idoxuridine against feline herpesvirus has the IC50 value of 4.3 μM.
体内研究：
Idoxuridine (intraperitoneal injection, 50-200 mg/kg, 3 times, 3 hours interval) hydrate can stimulate the production of hemolysin plaque-forming cells (HPFC) to sheep red blood cells (SRBC) in C3HeB/FeJ female and male mice and A/J male mice.Animal Model:C3HeB/FeJ female and male mice and A/J male mice, aged 2 to 4 months
Dosage:50-200 mg/kg
Administration:Intraperitoneal injection, 3 times, 3 hours interval
Result:Stimulated the production of hemolysin plaque-forming cells (HPFC) to sheep red blood cells (SRBC) in the dose range of 50-200 mg/kg.
体外研究：
Idoxuridine (2-10 μM, 72 hours)hydrate has the IC50 value of 4.3 μM of antiviral.
Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) hydrate is an iodinated thymidine analogue that competitively inhibits phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase and affecting viral replication. Idoxuridine against feline herpesvirus has the IC50 value of 4.3 μM.
体内研究：
Idoxuridine (intraperitoneal injection, 50-200 mg/kg, 3 times, 3 hours interval) hydrate can stimulate the production of hemolysin plaque-forming cells (HPFC) to sheep red blood cells (SRBC) in C3HeB/FeJ female and male mice and A/J male mice.Animal Model:C3HeB/FeJ female and male mice and A/J male mice, aged 2 to 4 months
Dosage:50-200 mg/kg
Administration:Intraperitoneal injection, 3 times, 3 hours interval
Result:Stimulated the production of hemolysin plaque-forming cells (HPFC) to sheep red blood cells (SRBC) in the dose range of 50-200 mg/kg.
体外研究：
Idoxuridine (2-10 μM, 72 hours)hydrate has the IC50 value of 4.3 μM of antiviral.
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