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编 号：F746791
分子式：C21H14N6O8S
分子量：510.44
分子式：C21H14N6O8S
分子量：510.44
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CAS No: 1710337-31-7
产品详情
生物活性：
GS-493 is a selective protein tyrosine phosphatase SHP2 (PTPN11) inhibitor with an IC50 of 71 nM. GS-493 is 29- and 45-fold more active toward SHP2 than related SHP1 and PTP1B. GS-493 blocks cellular motility and growth of cancer cells. Antitumor activity.
体内研究：
GS-493 (46 mg/kg; i.p.; daily for 27 days) inhibits tumor growth significantly in a murine xenograft model.Animal Model:Nude mouse xenograft model (strain NMRI nu/nu mice)
Dosage:46 mg/kg (45.93 mg in 3 mL DMSO per kg)
Administration:i.p.; daily for 27 days
Result:Inhibited tumor growth significantly.
体外研究：
GS-493 (0.0625-10 μM) blocks hepatocyte growth factor (HGF)-stimulated epithelial-mesenchymal transition of human pancreatic adenocarcinoma (HPAF) cells.GS-493 (40 μM, a couple of days) blocks growth of the human NSCL cancer cell line LXFA 526L in soft agar and decreases the number of tumor cell colonies to 32%.
GS-493 is a selective protein tyrosine phosphatase SHP2 (PTPN11) inhibitor with an IC50 of 71 nM. GS-493 is 29- and 45-fold more active toward SHP2 than related SHP1 and PTP1B. GS-493 blocks cellular motility and growth of cancer cells. Antitumor activity.
体内研究：
GS-493 (46 mg/kg; i.p.; daily for 27 days) inhibits tumor growth significantly in a murine xenograft model.Animal Model:Nude mouse xenograft model (strain NMRI nu/nu mice)
Dosage:46 mg/kg (45.93 mg in 3 mL DMSO per kg)
Administration:i.p.; daily for 27 days
Result:Inhibited tumor growth significantly.
体外研究：
GS-493 (0.0625-10 μM) blocks hepatocyte growth factor (HGF)-stimulated epithelial-mesenchymal transition of human pancreatic adenocarcinoma (HPAF) cells.GS-493 (40 μM, a couple of days) blocks growth of the human NSCL cancer cell line LXFA 526L in soft agar and decreases the number of tumor cell colonies to 32%.
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