产品
编 号：F746769
分子式：C26H23NO6S
分子量：477.53
分子式：C26H23NO6S
分子量：477.53
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CAS No: 170488-57-0
产品详情
生物活性：
Tubulin inhibitor 23 is a potent Tubulin inhibitor with an IC50 of 4.8 μM. Tubulin inhibitor 23 induces cell apoptosis. Tubulin inhibitor 23 shows antiangiogenic activity in a dose-dependent manner. Tubulin inhibitor 23 has the potential for the research of leukaemia.
体内研究：
Tubulin inhibitor 23 (2, 6 μM; add into embryo water) shows antiangiogenic activity in a dose-dependent manner.Tubulin inhibitor 23 (2, 6 μM; add into embryo water) suppresses the proliferation and metastasis of K562 cells in zebrafish xenografts in a dose-dependent manner.Animal Model:3hpf zebrafish embryos
Dosage:2.0, 6.0 μM
Administration:Add into embryo water
Result:Decreased the number and length of ISVs (intersegmental vessels) in a dose-dependent inhibition pattern.
Animal Model:Transgenic zebrafish (fil1:EGFP) (K562 cell xenograft)
Dosage:2, 6 μM
Administration:Add into embryo water
Result:Reduced intensities and decreased tumour area.
体外研究：
Tubulin inhibitor 23 (compound 29e) (0-100 μM) inhibits tubulin polymerisation (IC50=4.8 μM) and anti-angiogenesis (IC50=3.4 μM) in Zebrafish.Tubulin inhibitor 23 (0-200 nM; 48 h) induces cell apoptosis in a concentration-dependent manner.Tubulin inhibitor 23 (0-20 μM; 0-29 min) binds to the colchicine site of tubulin and inhibit the microtubule polymerisation.Tubulin inhibitor 23 (0.1, 1, 10 μM; 1 h) shows anti-angiogenesis activity with low toxicity (IC50=58.6 μM) in Human umbilical vein endothelial cells (HUVECs).
Tubulin inhibitor 23 is a potent Tubulin inhibitor with an IC50 of 4.8 μM. Tubulin inhibitor 23 induces cell apoptosis. Tubulin inhibitor 23 shows antiangiogenic activity in a dose-dependent manner. Tubulin inhibitor 23 has the potential for the research of leukaemia.
体内研究：
Tubulin inhibitor 23 (2, 6 μM; add into embryo water) shows antiangiogenic activity in a dose-dependent manner.Tubulin inhibitor 23 (2, 6 μM; add into embryo water) suppresses the proliferation and metastasis of K562 cells in zebrafish xenografts in a dose-dependent manner.Animal Model:3hpf zebrafish embryos
Dosage:2.0, 6.0 μM
Administration:Add into embryo water
Result:Decreased the number and length of ISVs (intersegmental vessels) in a dose-dependent inhibition pattern.
Animal Model:Transgenic zebrafish (fil1:EGFP) (K562 cell xenograft)
Dosage:2, 6 μM
Administration:Add into embryo water
Result:Reduced intensities and decreased tumour area.
体外研究：
Tubulin inhibitor 23 (compound 29e) (0-100 μM) inhibits tubulin polymerisation (IC50=4.8 μM) and anti-angiogenesis (IC50=3.4 μM) in Zebrafish.Tubulin inhibitor 23 (0-200 nM; 48 h) induces cell apoptosis in a concentration-dependent manner.Tubulin inhibitor 23 (0-20 μM; 0-29 min) binds to the colchicine site of tubulin and inhibit the microtubule polymerisation.Tubulin inhibitor 23 (0.1, 1, 10 μM; 1 h) shows anti-angiogenesis activity with low toxicity (IC50=58.6 μM) in Human umbilical vein endothelial cells (HUVECs).
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