产品
编 号：F746733
分子式：C30H31FN4O4S
分子量：562.65
分子式：C30H31FN4O4S
分子量：562.65
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CAS No: 1694638-70-4
产品详情
生物活性：
Cathepsin K inhibitor 3 (compound 23) is a highly selective cathepsin K inhibitor with an IC50 value of 0.5 nM. Cathepsin K inhibitor 3 has a favorable pharmacokinetic profile and may be used in osteoarthritis (OA) disease studies.
体内研究：
Cathepsin K inhibitor 3 (compound 23) (p.o., 0.03-15 mg/kg, daily, 4 days) results in a significant and dose-dependent reduction in uCTX-I, with an 81% reduction in uCTX-1 levels at 0.3 mg/kg and a slightly more complete reduction at 15 mg/kg in dog.The pharmacokinetic parameters of compound 23 ParametersCl(mL/min/kg)T1/2(h)%FRat13133Dog3.14.138Rhesus18.52.355
Cathepsin K inhibitor 3 (compound 23) is a highly selective cathepsin K inhibitor with an IC50 value of 0.5 nM. Cathepsin K inhibitor 3 has a favorable pharmacokinetic profile and may be used in osteoarthritis (OA) disease studies.
体内研究：
Cathepsin K inhibitor 3 (compound 23) (p.o., 0.03-15 mg/kg, daily, 4 days) results in a significant and dose-dependent reduction in uCTX-I, with an 81% reduction in uCTX-1 levels at 0.3 mg/kg and a slightly more complete reduction at 15 mg/kg in dog.The pharmacokinetic parameters of compound 23 ParametersCl(mL/min/kg)T1/2(h)%FRat13133Dog3.14.138Rhesus18.52.355
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