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编 号：F746650
分子式：C15H17FN4O2S
分子量：336.38
分子式：C15H17FN4O2S
分子量：336.38
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CAS No: 1672691-50-7
产品详情
生物活性：
JZP-MA-11 is a positron emission tomography (PET) ligand targeting the endocannabinoid α/β-hydrolase domain 6 (ABHD6) enzyme. JZP-MA-11 selectively inhibits ABHD6 with an IC50 value of 126 nM. JZP-MA-11 can cross the blood-brain barrier (BBB). [18F]JZP-MA-11 has?the?potential?for preclinical evaluation targeting the brain ABHD6 in mice and nonhuman primate (NHP).
体内研究：
JZP-MA-11 (1.5 mg/kg; 静脉给药; 示踪剂注射前 20 分钟) 导致大脑、肝脏、心脏和肾脏等富含 ABHD6 的器官的放射性摄取减少。 Animal Model:C57BL6 mice (female, 10-12-week-old)
Dosage:1.5 mg/kg
Administration:IV; 20 min before tracer injection
Result:Resulted in a decrease in radioactivity uptake in ABHD6-rich organs such as, brain, liver, heart, and kidneys.
体外研究：
JZP-MA-11 (10 μM) 对表达 CB1 或 CB2 的 HEK293 细胞中 毛喉素?(HY-15371) 刺激的 cAMP 没有影响。
JZP-MA-11 is a positron emission tomography (PET) ligand targeting the endocannabinoid α/β-hydrolase domain 6 (ABHD6) enzyme. JZP-MA-11 selectively inhibits ABHD6 with an IC50 value of 126 nM. JZP-MA-11 can cross the blood-brain barrier (BBB). [18F]JZP-MA-11 has?the?potential?for preclinical evaluation targeting the brain ABHD6 in mice and nonhuman primate (NHP).
体内研究：
JZP-MA-11 (1.5 mg/kg; 静脉给药; 示踪剂注射前 20 分钟) 导致大脑、肝脏、心脏和肾脏等富含 ABHD6 的器官的放射性摄取减少。 Animal Model:C57BL6 mice (female, 10-12-week-old)
Dosage:1.5 mg/kg
Administration:IV; 20 min before tracer injection
Result:Resulted in a decrease in radioactivity uptake in ABHD6-rich organs such as, brain, liver, heart, and kidneys.
体外研究：
JZP-MA-11 (10 μM) 对表达 CB1 或 CB2 的 HEK293 细胞中 毛喉素?(HY-15371) 刺激的 cAMP 没有影响。
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