产品
编 号:F746428
分子式:C22H24F2N4O4
分子量:446.45
产品类型
结构图
CAS No: 1638504-52-5
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产品详情
生物活性:
XZ426 is a potent integrase strand transfer inhibitor with anti- HIV activity.
体外研究:
Intasomes are the target of the latest generation of antiretroviral drugs, integrase (IN) strand transfer inhibitors (INSTI). To better understand how INSTIs interact with HIV intasomes, we assembled the complex with bictegravir (BIC), the leading second-generation INSTI and the most broadly effective of all clinically approved INSTIs. Among these, XZ426 is a lead candidate that has shown superior efficacy to all clinically used and developed compounds against known drug-resistant variants.