产品
编 号：F746415
分子量：8636
分子量：8636
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规格
价格
是否有货
1mg
询价
询价
结构图
CAS No: 1637637-70-7
产品详情
生物活性：
Pelacarsen (AKCEA-APO(a)-LRx) is a liver-specific antisense oligonucleotide against apolipoprotein(a) that reduces lipoprotein(a) up to 80% with good tolerability.
体内研究：
Mice dosed with Pelacarsen at dose levels of 0.3, 1, 3, and 10?mg/kg once weekly for 6 weeks had dose-dependent reductions in target mRNA expression. The model-estimated doses for Pelacarsen that produced 50% of maximum drug-induced inhibitory effect (ED50) for liver apo(a) mRNA and plasma apo(a) protein levels were 0.32 and 0.54?mg/kg/week, respectively.
Pelacarsen (AKCEA-APO(a)-LRx) is a liver-specific antisense oligonucleotide against apolipoprotein(a) that reduces lipoprotein(a) up to 80% with good tolerability.
体内研究：
Mice dosed with Pelacarsen at dose levels of 0.3, 1, 3, and 10?mg/kg once weekly for 6 weeks had dose-dependent reductions in target mRNA expression. The model-estimated doses for Pelacarsen that produced 50% of maximum drug-induced inhibitory effect (ED50) for liver apo(a) mRNA and plasma apo(a) protein levels were 0.32 and 0.54?mg/kg/week, respectively.
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