产品
编 号:F746306
分子式:C36H51ClN4O10
分子量:735.26
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1mg
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5mg
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10mg
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生物活性:
Maytansinoid B is a kind of ADC Cytotoxin. Maytansinoid B can be used to conjugates with antibodies to form antibody-drug conjugates (ADCs). Maytansinoids are known as antimitotic agents, binding to tubulin and inhibiting microtubule assembly. Maytansinoids induces G2/M arrest in the cell cycle to induce apoptosis.

体外研究:
Maytansinoid 对包括淋巴瘤系在内的几种肿瘤细胞系表现出 10-90 pM 的细胞毒活性。Maytansinoid 与抗 CD9 抗体结合,可形成 SAR3419 对抗 B 细胞恶性肿瘤。
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