产品
编 号：F746219
分子式：C20H13F2N5O3S
分子量：441.41
分子式：C20H13F2N5O3S
分子量：441.41
产品类型
规格
价格
是否有货
结构图
CAS No: 1621718-37-3
产品详情
生物活性：
PI3K/mTOR Inhibitor-13 is an orally active dual inhibitor of phosphoinositol 3-kinase (PI3K) and mTOR kinase. PI3K/mTOR Inhibitor-13 has potential applications in sexual diseases, solid tumor and idiopathic pulmonary fibrosis (IPF).
体内研究：
PI3K/mTOR Inhibitor-13 的药代动力学 (PK) 参数SpeciesAdministration mannerDose (mg/kg)T1/2 (h)AUClast (ng?h/mL)Cl/F (L/h/kg)Vss (L/kg) F (%)
RatIntravenous injection22.7770690.290.8594.75
MiceIntravenous injection15.45570590.020.1379.3
DogIntravenous injection10.6736720.270.23108.5
MonkeyIntravenous injection19.7059780.160.9259.8
体外研究：
PI3K/mTOR Inhibitor-13 (Compound A) (0-2 μM；48 h) 以剂量依赖性方式抑制 HFL1 细胞的增值。
PI3K/mTOR Inhibitor-13 is an orally active dual inhibitor of phosphoinositol 3-kinase (PI3K) and mTOR kinase. PI3K/mTOR Inhibitor-13 has potential applications in sexual diseases, solid tumor and idiopathic pulmonary fibrosis (IPF).
体内研究：
PI3K/mTOR Inhibitor-13 的药代动力学 (PK) 参数SpeciesAdministration mannerDose (mg/kg)T1/2 (h)AUClast (ng?h/mL)Cl/F (L/h/kg)Vss (L/kg) F (%)
RatIntravenous injection22.7770690.290.8594.75
MiceIntravenous injection15.45570590.020.1379.3
DogIntravenous injection10.6736720.270.23108.5
MonkeyIntravenous injection19.7059780.160.9259.8
体外研究：
PI3K/mTOR Inhibitor-13 (Compound A) (0-2 μM；48 h) 以剂量依赖性方式抑制 HFL1 细胞的增值。
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备