产品
编 号:F746215
分子式:C24H26Cl2FN5O2
分子量:506.4
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10mM*1mL in DMSO
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1mg
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5mg
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10mg
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生物活性:
Envonalkib is a potent and orally active inhibitor of ALK, with IC50s of 1.96 nM, 35.1 nM, and 61.3 nM for WT and mutated L1196M and G1269S-ALK. Envonalkib can be used for the research of non-small cell lung cancer.

体内研究:
Envonalkib (formula I) (12.5-25 mg/kg; p.o. once daily for 14 days) inhibits the growth of human non-small cell lung cancer NCI-H2228 nude mice xenografts.
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