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编 号:F746161
分子式:C19H17N5O
分子量:331.37
产品类型
结构图
CAS No: 1616385-51-3
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生物活性:
Bezuclastinib (CGT9486) is an orally active, highly selective tyrosine kinase inhibitor with potent activity against KIT D816V. Bezuclastinib can be used for the research of nonadvanced systemic mastocytosis (NonAdvSM).
体内研究:
Bezuclastinib (25 mg/kg, 口服, 3 天) 在大鼠中显示脑:血浆比率为 0.07。药代动力学分析RouteDose (mg/kg)t1/2 (h)Cmax (ng/mL)AUClast (h*ng/mL)
p.o.252.82592±36421509±2558