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编 号：F746141
分子式：C119H202N36O29
分子量：2601.1
分子式：C119H202N36O29
分子量：2601.1
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CAS No: 161374-99-8
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生物活性：
CD31 (PECAM-1) is platelet endothelial cell adhesion molecule-1, serves as the endothelial cell-specific receptor of clostridium perfringens b-Toxin (CPB). CD31 is also an ER-MP12 antigen, acts as a linker between mechanical stress, metabolism and inflammation. CD31 peptide is able to sustain phosphorylation of the CD31 ITIM686 and of SHP2 and to inhibit TCR-induced T-cell activation-.
体外研究：
CD31 is a trans-homophilic co-signaling protein at the crossroad between mechanical stress, metabolism and inflammation.CD31 is a ER-MP12 antigen, exerts function as promoting cell adhesion between endothelial cells, enabling transmigration of leukocytes across vascular endothelium, and producing signaling to up-regulation of other adhesion molecules in neighboring cells.Clostridium perfringens b-toxin (CPB) is a highly active b-pore-forming toxin (b-PFT) and the essential virulence factor for fatal, necro-hemorrhagic enteritis.CD31 serves as the specific membrane receptor for clostridium perfringens b-toxin (CPB) on endothelial cells. CD31 directly interacts with CPB, with the membrane proximal Ig6 domain.CD31 also serves as a therapeutic target in atherosclerosis.CD31 (0, 25, 50, 100 μg/mL) induces proliferative response to TCR engagement of human PBMCs in a dose-dependent manner.
CD31 (PECAM-1) is platelet endothelial cell adhesion molecule-1, serves as the endothelial cell-specific receptor of clostridium perfringens b-Toxin (CPB). CD31 is also an ER-MP12 antigen, acts as a linker between mechanical stress, metabolism and inflammation. CD31 peptide is able to sustain phosphorylation of the CD31 ITIM686 and of SHP2 and to inhibit TCR-induced T-cell activation-.
体外研究：
CD31 is a trans-homophilic co-signaling protein at the crossroad between mechanical stress, metabolism and inflammation.CD31 is a ER-MP12 antigen, exerts function as promoting cell adhesion between endothelial cells, enabling transmigration of leukocytes across vascular endothelium, and producing signaling to up-regulation of other adhesion molecules in neighboring cells.Clostridium perfringens b-toxin (CPB) is a highly active b-pore-forming toxin (b-PFT) and the essential virulence factor for fatal, necro-hemorrhagic enteritis.CD31 serves as the specific membrane receptor for clostridium perfringens b-toxin (CPB) on endothelial cells. CD31 directly interacts with CPB, with the membrane proximal Ig6 domain.CD31 also serves as a therapeutic target in atherosclerosis.CD31 (0, 25, 50, 100 μg/mL) induces proliferative response to TCR engagement of human PBMCs in a dose-dependent manner.
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