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编 号：F746050
分子式：C28H41NO8
分子量：519.63
分子式：C28H41NO8
分子量：519.63
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CAS No: 1609105-89-6
产品详情
生物活性：
Thailanstatin D, an analogue of Thailanstatin A, is able to inhibit AR-V7 gene splicing by interfering the interaction between U2AF65 and SAP155 and preventing them from binding to polypyrimidine tract located between the branch point and the 3' splice site. Thailanstatin D exhibits a potent tumor inhibitory effect on human CRPC xenografts leading to cell apoptosis.
体内研究：
Thailanstatin D (300 μg/kg; ALZET osmotic pumps; daily for 4 days) significantly inhibits the tumor growth.Animal Model:NOD-SCID mice ( Mice bearing 22RV1 xenografts)
Dosage:300 μg/kg
Administration:ALZET osmotic pumps; daily for 4 days
Result:Significantly inhibited the tumor growth.
体外研究：
Thailanstatin D (0-50 nM; 4 hours) significantly decreases the protein levels of AR-V7 and other AR-Vs (AR splice variants).
Thailanstatin D, an analogue of Thailanstatin A, is able to inhibit AR-V7 gene splicing by interfering the interaction between U2AF65 and SAP155 and preventing them from binding to polypyrimidine tract located between the branch point and the 3' splice site. Thailanstatin D exhibits a potent tumor inhibitory effect on human CRPC xenografts leading to cell apoptosis.
体内研究：
Thailanstatin D (300 μg/kg; ALZET osmotic pumps; daily for 4 days) significantly inhibits the tumor growth.Animal Model:NOD-SCID mice ( Mice bearing 22RV1 xenografts)
Dosage:300 μg/kg
Administration:ALZET osmotic pumps; daily for 4 days
Result:Significantly inhibited the tumor growth.
体外研究：
Thailanstatin D (0-50 nM; 4 hours) significantly decreases the protein levels of AR-V7 and other AR-Vs (AR splice variants).
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