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编 号：F745814
分子式：C32H52O6
分子量：532.75
分子式：C32H52O6
分子量：532.75
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CAS No: 156312-07-1
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生物活性：
Dictyostatin ((-)-Dictyostatin; Dictyostatin 1) is a potent microtubule stabilizing agent. Dictyostatin also is a anti-cancer agent. Dictyostatin shows antiproliferative activity. Dictyostatin has the potential for the research of tauopathies.
体内研究：
Dictyostatin (0.3、1 mg/kg；腹腔注射；每周一次，持续 3 个月) 可改善小鼠的 MT 密度并减少轴突营养不良。Animal Model:6-month old male B6 PS19 tau Tg mice
Dosage:0.3, 1 mg/kg
Administration:I.p.; once-weekly for 3 months
Result:Improved MT density and reduced axonal dystrophy, with a reduction of tau pathology and a trend toward increased hippocampal neuron survival relative to vehicle-treated PS19 mice, caused a significant reduction of insoluble TauAcK280.
体外研究：
Dictyostatin (0-100 nM; 72-120 h) 在癌细胞中显示出抗增殖活性。
Dictyostatin ((-)-Dictyostatin; Dictyostatin 1) is a potent microtubule stabilizing agent. Dictyostatin also is a anti-cancer agent. Dictyostatin shows antiproliferative activity. Dictyostatin has the potential for the research of tauopathies.
体内研究：
Dictyostatin (0.3、1 mg/kg；腹腔注射；每周一次，持续 3 个月) 可改善小鼠的 MT 密度并减少轴突营养不良。Animal Model:6-month old male B6 PS19 tau Tg mice
Dosage:0.3, 1 mg/kg
Administration:I.p.; once-weekly for 3 months
Result:Improved MT density and reduced axonal dystrophy, with a reduction of tau pathology and a trend toward increased hippocampal neuron survival relative to vehicle-treated PS19 mice, caused a significant reduction of insoluble TauAcK280.
体外研究：
Dictyostatin (0-100 nM; 72-120 h) 在癌细胞中显示出抗增殖活性。
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