产品
编 号：F745646
分子式：C23H22FN7O2
分子量：447.46
分子式：C23H22FN7O2
分子量：447.46
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 1517965-94-4
产品详情
生物活性：
Vornorexant (ORN-0829; TS-142) is a potent dual OX1R and OX2R antagonist with IC50 values of 1.05 nM and 1.27 nM, respectively. Vornorexant exhibits potent sleep-promoting effects in vivo and can be used for insomnia research research.
体内研究：
Vornorexant (oral administration; 1-10 mg/kg) exhibits potent sleep-promoting effects at a po. dose of 1 mg/kg in a rat polysomnogram study. It results in a dose-dependent increase in the percentage of total sleep.Vornorexant exhibits optimal PK properties with a rapid Tmax?and short half-lives in rats and dogs. The T1/2 is 0.238 hours and 1.16 hours, respectively in rat and dog.Animal Model:Rat
Dosage:1, 3, 10 mg/kg
Administration:Oral administration to rats prior to turning the light off (start of the active phase); 1-10 mg/kg
Result:Possessed promising sleep-inducing and sleep-promoting effects.
Vornorexant (ORN-0829; TS-142) is a potent dual OX1R and OX2R antagonist with IC50 values of 1.05 nM and 1.27 nM, respectively. Vornorexant exhibits potent sleep-promoting effects in vivo and can be used for insomnia research research.
体内研究：
Vornorexant (oral administration; 1-10 mg/kg) exhibits potent sleep-promoting effects at a po. dose of 1 mg/kg in a rat polysomnogram study. It results in a dose-dependent increase in the percentage of total sleep.Vornorexant exhibits optimal PK properties with a rapid Tmax?and short half-lives in rats and dogs. The T1/2 is 0.238 hours and 1.16 hours, respectively in rat and dog.Animal Model:Rat
Dosage:1, 3, 10 mg/kg
Administration:Oral administration to rats prior to turning the light off (start of the active phase); 1-10 mg/kg
Result:Possessed promising sleep-inducing and sleep-promoting effects.
产品资料
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