产品
编 号：F745618
分子式：C106H216N10O10
分子量：1790.91
分子式：C106H216N10O10
分子量：1790.91
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
结构图
CAS No: 1510653-27-6
产品详情
生物活性：
G0-C14 is a cationic lipid-like compound alkyl-modified polyamidoamine (PAMAM) dendrimer. G0-C14 involves in the preparation of a series of macrophage-targeted nanoparticles (NPs). NPs can be used for agent and vaccine delivery.
体外研究：
G0-C14 exhibits strong entrapment of mRNA and pDNA with an encapsulation efficiency of above 95%.Preparation of NPs:1.Dissolve PolyHCPT and DSPE-PEG3K in DMF to form a homogenous solution at a concentration of 5 mg/mL.2.Prepare a mixture of 1 nmol of siRNA (0.1 nmol/μL aqueous solution) and G0-C14 (5 mg/mL in DMF) in different N/P molar ratios. Mixed them with the polyHCPT and DSPE-PEG3K solution.3.Under vigorous stirring (1000 rpm), add the mixture dropwise to 5 mL of deionized water. 4.Transferr the formed NP dispersion to an ultrafiltration device.5.Ccentrifug at room temperature (2800 rpm×8 min) to remove the organic solvent and freecompounds.
G0-C14 is a cationic lipid-like compound alkyl-modified polyamidoamine (PAMAM) dendrimer. G0-C14 involves in the preparation of a series of macrophage-targeted nanoparticles (NPs). NPs can be used for agent and vaccine delivery.
体外研究：
G0-C14 exhibits strong entrapment of mRNA and pDNA with an encapsulation efficiency of above 95%.Preparation of NPs:1.Dissolve PolyHCPT and DSPE-PEG3K in DMF to form a homogenous solution at a concentration of 5 mg/mL.2.Prepare a mixture of 1 nmol of siRNA (0.1 nmol/μL aqueous solution) and G0-C14 (5 mg/mL in DMF) in different N/P molar ratios. Mixed them with the polyHCPT and DSPE-PEG3K solution.3.Under vigorous stirring (1000 rpm), add the mixture dropwise to 5 mL of deionized water. 4.Transferr the formed NP dispersion to an ultrafiltration device.5.Ccentrifug at room temperature (2800 rpm×8 min) to remove the organic solvent and freecompounds.
产品资料
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