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编 号：F745590
分子式：C23H28O10S
分子量：496.53
分子式：C23H28O10S
分子量：496.53
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CAS No: 1502721-60-9
产品详情
生物活性：
Antibacterial agent 130 is a 1,1-diarylthiogalactoside, used for targeting the Pseudomonas aeruginosa LecA. Antibacterial agent 130 shows high affinity toward LecA (Kd=1 μM). Antibacterial agent 130 has antibiofilm activity, but lacks bactericidal activity. LecA, a lectin and virulence factor from Pseudomonas aeruginosa involved in bacterial adhesion and biofilm formation.
体外研究：
Antibacterial agent 130 (化合物 8a) (0.08-5 mM; 2-24 h) 剂量依赖性抑制细菌生物膜的形成，在 5 mM 剂量下的抑制率是 100%。Antibacterial agent 130 (0.01-5 mM; 24 h) 浓度高于1.25 mM 时对 MRC-5 细胞系 (人胎儿肺成纤维细胞) 有细胞毒性。
Antibacterial agent 130 is a 1,1-diarylthiogalactoside, used for targeting the Pseudomonas aeruginosa LecA. Antibacterial agent 130 shows high affinity toward LecA (Kd=1 μM). Antibacterial agent 130 has antibiofilm activity, but lacks bactericidal activity. LecA, a lectin and virulence factor from Pseudomonas aeruginosa involved in bacterial adhesion and biofilm formation.
体外研究：
Antibacterial agent 130 (化合物 8a) (0.08-5 mM; 2-24 h) 剂量依赖性抑制细菌生物膜的形成，在 5 mM 剂量下的抑制率是 100%。Antibacterial agent 130 (0.01-5 mM; 24 h) 浓度高于1.25 mM 时对 MRC-5 细胞系 (人胎儿肺成纤维细胞) 有细胞毒性。
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