产品
编 号：F745553
分子式：C26H21F4N7O3S
分子量：587.55
分子式：C26H21F4N7O3S
分子量：587.55
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 1496509-78-4
产品详情
生物活性：
Nenocorilantis a potent, orally activity glucocorticoid receptor (GR) antagonist with Ki value of 0.15 nM. Nenocorilant has pro-apoptotic effects and improves potency combined with cytotoxic agent. Nenocorilant can be used for cancer research.
体内研究：
Nenocorilant (30 mg/kg; p.o.; once every four days, for 25 d; female Balb/c nude mice) improves the efficacy and promotes apoptotic activity of cytotoxic therapy in xenograft models under physiological cortisol conditions.Animal Model:Female Balb/c nude mice
Dosage:30 mg/kg
Administration:Oral administration; once every four days, for 25 days
Result:Inhibited tumor growth and increased the expression level of caspase 3.
体外研究：
Nenocorilant (0-1000 nM; 0-72 h; OvCa cells) has pro-apoptotic effects and reverses the effects of cortisol and partially restored Paclitaxel and Gemcitabine induction of tumor-cell apoptosis.Nenocorilant (100 nM; 4 h; MIA PaCa-2 and OVCAR5 cells) prevents dex-mediated upregulation of both GR target genes SGK1 and MKP1.
Nenocorilantis a potent, orally activity glucocorticoid receptor (GR) antagonist with Ki value of 0.15 nM. Nenocorilant has pro-apoptotic effects and improves potency combined with cytotoxic agent. Nenocorilant can be used for cancer research.
体内研究：
Nenocorilant (30 mg/kg; p.o.; once every four days, for 25 d; female Balb/c nude mice) improves the efficacy and promotes apoptotic activity of cytotoxic therapy in xenograft models under physiological cortisol conditions.Animal Model:Female Balb/c nude mice
Dosage:30 mg/kg
Administration:Oral administration; once every four days, for 25 days
Result:Inhibited tumor growth and increased the expression level of caspase 3.
体外研究：
Nenocorilant (0-1000 nM; 0-72 h; OvCa cells) has pro-apoptotic effects and reverses the effects of cortisol and partially restored Paclitaxel and Gemcitabine induction of tumor-cell apoptosis.Nenocorilant (100 nM; 4 h; MIA PaCa-2 and OVCAR5 cells) prevents dex-mediated upregulation of both GR target genes SGK1 and MKP1.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备