产品
编 号：F745493
分子式：C26H21FN8
分子量：464.5
分子式：C26H21FN8
分子量：464.5
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 1481617-15-5
产品详情
生物活性：
Ipivivint (compound 38) is a potent CDC-like kinase (CLK) inhibitor with EC50s of 1 nM, 7 nM for CLK2 and CLK3, respectively. Ipivivint inhibits Wnt pathway (EC50=13 nM).
体内研究：
Animal Model:Foxn1 mice
Dosage:25 mg/kg
Administration:P.o.
Result:Potently inhibited tumor SRSF6 phosphorylation.
体外研究：
0-->Ipivivint 相关抗体:Western Blot AnalysisCell Line:SW480 cells
Concentration:0.01~10 μM
Incubation Time:1 hour
Result:Potently inhibited SRSF5/6 phosphorylation.
Apoptosis AnalysisCell Line:SW480 cells
Concentration:0.01~10 μM
Incubation Time:0.03 μM~3 μM
Result:Induced apoptosis.
RT-PCRCell Line:HEK-293T cells
Concentration:0.3~3 μM
Incubation Time:1 hour
Result:Inhibited Wnt/β-catenin signaling induced by Wnt3a.
ImmunofluorescenceCell Line:SW480 cells
Concentration:0.3~10 μM
Incubation Time:6 hours
Result:Increased nuclear speckle enlargement.
Ipivivint (compound 38) is a potent CDC-like kinase (CLK) inhibitor with EC50s of 1 nM, 7 nM for CLK2 and CLK3, respectively. Ipivivint inhibits Wnt pathway (EC50=13 nM).
体内研究：
Animal Model:Foxn1 mice
Dosage:25 mg/kg
Administration:P.o.
Result:Potently inhibited tumor SRSF6 phosphorylation.
体外研究：
0-->Ipivivint 相关抗体:Western Blot AnalysisCell Line:SW480 cells
Concentration:0.01~10 μM
Incubation Time:1 hour
Result:Potently inhibited SRSF5/6 phosphorylation.
Apoptosis AnalysisCell Line:SW480 cells
Concentration:0.01~10 μM
Incubation Time:0.03 μM~3 μM
Result:Induced apoptosis.
RT-PCRCell Line:HEK-293T cells
Concentration:0.3~3 μM
Incubation Time:1 hour
Result:Inhibited Wnt/β-catenin signaling induced by Wnt3a.
ImmunofluorescenceCell Line:SW480 cells
Concentration:0.3~10 μM
Incubation Time:6 hours
Result:Increased nuclear speckle enlargement.
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