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编 号:F745328
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1mg
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生物活性:
Asunercept (APG101; CAN008) is a soluble CD95-Fc fusion protein targeting CD95L. Asunercept disrupts CD95/CD95L signaling by selectively binding to CD95L. Asunercept can be used in the research of glioblastoma multiforme (GBM), myelodysplastic syndrome (MDS), and graft-versus-host disease (GvHD).

体外研究:
Asunercept (APG101; 0-100 μg/mL; preincubation for 30 min) 能特异性中和重组 CD95L 的促凋亡活性。Asunercept (0.2, 2, 20 μg/mL; 72 h) 能够干扰 CD95 诱导的胶质瘤细胞的迁移/侵袭。
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