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编 号:F745290
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CAS No: 1448221-05-3
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生物活性:
Vanucizumab is a first-in-class, bispecific IgG1-like monoclonal antibody that simultaneously blocks VEGF-A and angiopoietin-2 (Ang-2) from interacting with their receptors. Vanucizumab has antiangiogenic and anticancer effects.
体内研究:
Vanucizumab (20mg /kg;i.p。每周1次;6周) 显示肿瘤生长抑制和诱导肿瘤停滞。Animal Model:SCID beige mice bearing Colo205 cells
Dosage:20 mg/kg
Administration:i.p.; once weekly; for 6 weeks
Result:Showed tumor growth inhibition.