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编 号：F745275
分子式：C10H17NO5
分子量：231.25
分子式：C10H17NO5
分子量：231.25
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CAS No: 1446971-41-0
产品详情
生物活性：
ZLc-002 is a selective inhibitor of nNOS-Capon coupling. ZLc-002 suppresses inflammatory nociception and chemotherapy-induced neuropathic pain. ZLc-002 can be used for the research of anxiety disorder and inflammation.
体内研究：
ZLc-002 (30 mg/kg; i.p. from 4-10 days until 46 days after stroke everyday) improves motor function in tMCAO mice.ZLc-002 (40 mg/kg; i.v. once per day for seven days) improves chronic mild stress (CMS)-induced anxiety-related behaviours.ZLc-002 (10 μM 1 μL; hippocampus injection once per day for seven days) improves corticosterone (CORT)-induced anxiety-related behaviours.Animal Model:tMCAO mice
Dosage:30 mg/kg
Administration:Intraperitoneal injection; 30 mg/kg per day; from 4–10 days until 46 days after stroke
Result:Signally ameliorated sroke-induced impairment of motor function and recovered from stroke in the delayed phase.
Animal Model:Adult male ICR mice with CMS exposure
Dosage:40 mg/kg
Administration:Intravenous injection; 40 mg/kg once per day; from 21-27 days of CMS exposure for 7 days
Result:Showed a therapeutic effect in CMS-induced anxiety disorder.
Animal Model:Adult male ICR mice with CORT
Dosage:10 μM 1 μL
Administration:Hippocampus injection; 10 μM 1 μL once per day; from 21-27 days of CORT reatmentfor 7 days
Result:Showed a therapeutic effect in chronic stress-induced anxiety disorders.
体外研究：
ZLc-002 (1 μM; 24 h) inhibits nNOS-CAPON in cultured hippocampal neurons from ICR mice.
ZLc-002 is a selective inhibitor of nNOS-Capon coupling. ZLc-002 suppresses inflammatory nociception and chemotherapy-induced neuropathic pain. ZLc-002 can be used for the research of anxiety disorder and inflammation.
体内研究：
ZLc-002 (30 mg/kg; i.p. from 4-10 days until 46 days after stroke everyday) improves motor function in tMCAO mice.ZLc-002 (40 mg/kg; i.v. once per day for seven days) improves chronic mild stress (CMS)-induced anxiety-related behaviours.ZLc-002 (10 μM 1 μL; hippocampus injection once per day for seven days) improves corticosterone (CORT)-induced anxiety-related behaviours.Animal Model:tMCAO mice
Dosage:30 mg/kg
Administration:Intraperitoneal injection; 30 mg/kg per day; from 4–10 days until 46 days after stroke
Result:Signally ameliorated sroke-induced impairment of motor function and recovered from stroke in the delayed phase.
Animal Model:Adult male ICR mice with CMS exposure
Dosage:40 mg/kg
Administration:Intravenous injection; 40 mg/kg once per day; from 21-27 days of CMS exposure for 7 days
Result:Showed a therapeutic effect in CMS-induced anxiety disorder.
Animal Model:Adult male ICR mice with CORT
Dosage:10 μM 1 μL
Administration:Hippocampus injection; 10 μM 1 μL once per day; from 21-27 days of CORT reatmentfor 7 days
Result:Showed a therapeutic effect in chronic stress-induced anxiety disorders.
体外研究：
ZLc-002 (1 μM; 24 h) inhibits nNOS-CAPON in cultured hippocampal neurons from ICR mice.
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