产品
编 号：F745269
分子式：C21H19N9O3S
分子量：477.5
分子式：C21H19N9O3S
分子量：477.5
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CAS No: 1446715-47-4
产品详情
生物活性：
SR-1277 is a potent, selective and ATP competitive CK1δ/ε inhibitor, with IC50s of 49 nM and 260 nM, respectively. SR-1277 also inhibits FLT3, CDK4/cyclin D1, CDK6/cyclin D3 and CDK9/cyclin K, with IC50s of 305 nM, 1340 nM, 311 nM and 109 nM, respectively. SR-1277 can be used for the research of cancer.
体内研究：
SR-1277 (1 mg/kg; i.v.) exhibits Cmax (1.2 μM), Cl (2.8 ml/min/kg), AUC(1.26 μM?h), T1/2 (1.42 h) and brain penetration (24%) in mice.
体外研究：
SR-1277 exhibits antiproliferative effects in A375 cells, with an EC50 of 22 nM.
SR-1277 is a potent, selective and ATP competitive CK1δ/ε inhibitor, with IC50s of 49 nM and 260 nM, respectively. SR-1277 also inhibits FLT3, CDK4/cyclin D1, CDK6/cyclin D3 and CDK9/cyclin K, with IC50s of 305 nM, 1340 nM, 311 nM and 109 nM, respectively. SR-1277 can be used for the research of cancer.
体内研究：
SR-1277 (1 mg/kg; i.v.) exhibits Cmax (1.2 μM), Cl (2.8 ml/min/kg), AUC(1.26 μM?h), T1/2 (1.42 h) and brain penetration (24%) in mice.
体外研究：
SR-1277 exhibits antiproliferative effects in A375 cells, with an EC50 of 22 nM.
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