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编 号:F745250
分子式:C19H26O3
分子量:302.41
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生物活性:
Isograndifoliol is a selective inhibitor of butyrylcholinesterase (BChE) with an IC50 value of 0.9 μM. And Isograndifoliol moderately inhibits acetylcholinesterase (AChE) with an IC50 value of 342.9 μM. Isograndifoliol also has vasorelaxant effect and anti-tumor effect. Isograndifoliol can be used for research against dementia caused by neurodegenerative diseases.

体外研究:
Isograndifoliol 对氯化钾或去甲肾上腺素预缩大鼠主动脉环具有剂量依赖性的血管松弛作用,EC50值为 36.36-74.51 μg/mL。Isograndifoliol 对 HL-60 细胞有较强的抑制活性,IC50 值为 0.33 μM。
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