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编 号：F745239
分子量：6584
分子量：6584
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CAS No: 1443994-46-4
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生物活性：
Mongersen (GED-0301) is a specific and orally active SMAD7 antisense oligonucleotide. Mongersen restores TGF-β1 activity leading to inhibition of inflammatory signals. Mongersen can attenuate Crohn's disease-like experimental colitis in mice.
体内研究：
Mongersen (125 μg/mouse; p.o. twice a week for 3 weeks) reduces TNBS- or DSS-induced colonic inflammation and colonic fibrosis of mice.Animal Model:Eight-week-old female BALB/c mice were treated with TNBS
Dosage:125 μg/mouse
Administration:Oral gavage, twice a week starting from week 5 or week 9 for 3 weeks
Result:Reduced Smad7 protein expression.Attenuated the ongoing colonic inflammation.Significantly reduced TNF-α and IL-6 RNA expression. Attenuated colonic fibrosis.
Mongersen (GED-0301) is a specific and orally active SMAD7 antisense oligonucleotide. Mongersen restores TGF-β1 activity leading to inhibition of inflammatory signals. Mongersen can attenuate Crohn's disease-like experimental colitis in mice.
体内研究：
Mongersen (125 μg/mouse; p.o. twice a week for 3 weeks) reduces TNBS- or DSS-induced colonic inflammation and colonic fibrosis of mice.Animal Model:Eight-week-old female BALB/c mice were treated with TNBS
Dosage:125 μg/mouse
Administration:Oral gavage, twice a week starting from week 5 or week 9 for 3 weeks
Result:Reduced Smad7 protein expression.Attenuated the ongoing colonic inflammation.Significantly reduced TNF-α and IL-6 RNA expression. Attenuated colonic fibrosis.
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