产品
编 号:F745210
分子式:C31H47F3N8O7
分子量:700.75
产品类型
结构图
CAS No: 1442106-11-7
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生物活性:
MM-401 (TFA) is a MLL1 H3K4 methyltransferase inhibitor. MM-401 inhibits MLL1 activity (IC50 = 0.32 μM) by blocking MLL1-WDR5 interaction. MM-401 can induce cell cycle arrest, apoptosis and differentiation. MM-401 can be used for the research of MLL leukemia.
体外研究:
MM-401 maintains high binding affinity to WDR5 with a Ki value of MM-401 TFA 相关抗体:Apoptosis AnalysisCell Line:Murine MLL-AF9 and Hoxa9/Meis1 cells
Concentration:10, 20, 40 μM
Incubation Time:48 h
Result:Specifically induced apoptosis of MLL-AF9 cells.
Cell Cycle AnalysisCell Line:Murine MLL-AF9 and Hoxa9/Meis1 cells
Concentration:10, 20, 40 μM
Incubation Time:48 h
Result:Induced prominent G1/S arrest in MLL-AF9 cells in a concentration dependent manner.
RT-PCRCell Line:MLL-AF9 cells
Concentration:20 μM
Incubation Time:48 h
Result:Significantly decreased H3K4me, expression of 5 Hox A genes, especially Hoxa9 and Hoxa10.