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编 号：F745156
分子式：C15H11N9Na2O
分子量：379.29
分子式：C15H11N9Na2O
分子量：379.29
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CAS No: 143330-46-5
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生物活性：
Andolast (CR 2039) is an anti-allergic agent. Andolast can inhibit cAMP-phosphodiesterase with an IC50 value of 50 μM. Andolast can be used for the research of asthma.
体内研究：
Andolast (CR 2039) (i.v. or i.m.) inhibits rat passive cutaneous anaphylaxis (PCA) with an ED50 of 0.1 mg/kg.CR 2039 (10-100 mg/kg; i.v. or i.m.) inhibits the microvascular permeability changes in a model of allergic conjunctivitis in sensitized guinea-pigs.CR 2039 (0-1000 μM; i.v.) inhibits dose dependently guinea-pig lung cAMP-phosphodiesterase with an IC50 value of 50 μM.Animal Model:Male Hartley guinea-pigs (300-500 g)
Dosage:10-100 mg/kg
Administration:I.M; I.V.
Result:Showed dose-related significant protection against lgE-dependent bronchial anaphylaxis induced by aerosolized antigen in anesthetized guinea-pigs.Delayed dose dependently the onset of bronchoconstriction induced by aerosolized antigen.
Andolast (CR 2039) is an anti-allergic agent. Andolast can inhibit cAMP-phosphodiesterase with an IC50 value of 50 μM. Andolast can be used for the research of asthma.
体内研究：
Andolast (CR 2039) (i.v. or i.m.) inhibits rat passive cutaneous anaphylaxis (PCA) with an ED50 of 0.1 mg/kg.CR 2039 (10-100 mg/kg; i.v. or i.m.) inhibits the microvascular permeability changes in a model of allergic conjunctivitis in sensitized guinea-pigs.CR 2039 (0-1000 μM; i.v.) inhibits dose dependently guinea-pig lung cAMP-phosphodiesterase with an IC50 value of 50 μM.Animal Model:Male Hartley guinea-pigs (300-500 g)
Dosage:10-100 mg/kg
Administration:I.M; I.V.
Result:Showed dose-related significant protection against lgE-dependent bronchial anaphylaxis induced by aerosolized antigen in anesthetized guinea-pigs.Delayed dose dependently the onset of bronchoconstriction induced by aerosolized antigen.
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