产品
编 号：F745094
分子式：C23H31N5O6
分子量：473.52
分子式：C23H31N5O6
分子量：473.52
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 1428862-33-2
产品详情
生物活性：
Usmarapride (SUVN-D4010) is a potent, selective, orally active and brain penetrant 5-HT4 receptor partial agonist (EC50=44 nM). Usmarapride (SUVN-D4010) can be used for the research of cognitive deficits associated with Alzheimer's disease.
体内研究：
Usmarapride (SUVN-D4010) (1-3 mg/kg; p.o.; Male Wistar rats 10-12 weeks old) attenuates the long-term memory deficits in object recognition test (ORT).Usmarapride (1, 3, and 10 mg/kg; p.o.) significantly reverses the scopolamine-induced amnesia. Usmarapride shows a statistically significant effect at 3.0 mg/kg on both exploration time and recognition index.Usmarapride (SUVN-D4010) shows good oral exposures, good bioavailability, and good brain exposures in rats.Pharmacokinetic of Usmarapride in Rats(3.0 mg/kg for p.o. dosing; 1.0 mg/kg for i.v.)F%Cmax (ng/mL)AUC (ng·hr/mL)t1/2 (h)Vdss (L/kg)CL (mLg/min/kg)
34 360 709 1.7 8.0 76
Usmarapride (SUVN-D4010) is a potent, selective, orally active and brain penetrant 5-HT4 receptor partial agonist (EC50=44 nM). Usmarapride (SUVN-D4010) can be used for the research of cognitive deficits associated with Alzheimer's disease.
体内研究：
Usmarapride (SUVN-D4010) (1-3 mg/kg; p.o.; Male Wistar rats 10-12 weeks old) attenuates the long-term memory deficits in object recognition test (ORT).Usmarapride (1, 3, and 10 mg/kg; p.o.) significantly reverses the scopolamine-induced amnesia. Usmarapride shows a statistically significant effect at 3.0 mg/kg on both exploration time and recognition index.Usmarapride (SUVN-D4010) shows good oral exposures, good bioavailability, and good brain exposures in rats.Pharmacokinetic of Usmarapride in Rats(3.0 mg/kg for p.o. dosing; 1.0 mg/kg for i.v.)F%Cmax (ng/mL)AUC (ng·hr/mL)t1/2 (h)Vdss (L/kg)CL (mLg/min/kg)
34 360 709 1.7 8.0 76
产品资料
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