产品
编 号：F744988
分子式：C29H40N6O8S
分子量：632.73
分子式：C29H40N6O8S
分子量：632.73
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 1422955-52-9
产品详情
生物活性：
TPN729MA (TPN729 maleate) is a selective phosphodiesterase type 5 (PDE5) inhibitor with an IC50 value of 2.28 nM. TPN729MA affects erectile function and it can be used for the research of erectile dysfunction.
体内研究：
TPN729MA (1.25，2.5，5.0 mg/kg；1 次) 在所有时间点 5.0 mg/kg 剂量下增加海绵内压/血压比值 (ICP/BP)，在 2.5 mg/kg 剂量下 75，90，105 和 120 分钟时增加海绵内压/血压比。TPN729MA (5.0 μg/kg；静脉注射，1 次) 显著升高公比格犬的海绵内压和海绵内压/血压比。Animal Model:Male Sprague-Dawley rats with corpora cavernosa complete exposure
Dosage:1.25, 2.5 and 5.0 mg/kg
Administration:Intraduodenal (i.d.) injection; 1.25, 2.5 and 5.0 mg/kg, once
Result:Dose-dependently increased the maximum intracavernous pressure (ICP) and ICP/blood pressure (BP).
TPN729MA (TPN729 maleate) is a selective phosphodiesterase type 5 (PDE5) inhibitor with an IC50 value of 2.28 nM. TPN729MA affects erectile function and it can be used for the research of erectile dysfunction.
体内研究：
TPN729MA (1.25，2.5，5.0 mg/kg；1 次) 在所有时间点 5.0 mg/kg 剂量下增加海绵内压/血压比值 (ICP/BP)，在 2.5 mg/kg 剂量下 75，90，105 和 120 分钟时增加海绵内压/血压比。TPN729MA (5.0 μg/kg；静脉注射，1 次) 显著升高公比格犬的海绵内压和海绵内压/血压比。Animal Model:Male Sprague-Dawley rats with corpora cavernosa complete exposure
Dosage:1.25, 2.5 and 5.0 mg/kg
Administration:Intraduodenal (i.d.) injection; 1.25, 2.5 and 5.0 mg/kg, once
Result:Dose-dependently increased the maximum intracavernous pressure (ICP) and ICP/blood pressure (BP).
产品资料
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