产品
编 号：F744884
分子式：C194H312N54O59S2
分子量：4409.01
分子式：C194H312N54O59S2
分子量：4409.01
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 1415456-99-3
产品详情
生物活性：
Cagrilintide is an investigational novel long-acting acylated amylin analogue, acts as nonselective amylin receptors (AMYR) and calcitonin G protein-coupled receptor (CTR) agonist. Cagrilintide induces significant weight loss and reduces food intake. Cagrilintide has the potential for the research of obesity.
体内研究：
Cagrilintide (compound 23) (0.1, 1, 3, 10, 30 nmol/kg; s.c.) reduces food intake in the rat.Cagrilintide (10 nmol/kg; i.v. or s.c.) shows good pharmacokinetic parameters.Animal Model:12 weeks, 400 g Sprague Dawley male rats
Dosage:0.1, 1, 3, 10, 30 nmol/kg
Administration:S.c.; once for 80 h
Result:Reduced food intake in the rat for several days at doses in the range of 1-10 nmol/kg.
Animal Model:12 weeks, 400 g Sprague Dawley male rats
Dosage:10 nmol/kg
Administration:I.v.; s.c.
Result:Showed good pharmacokinetic parameters with T1/2 of 20±2, 27±3 h for i.v. and s.c., respectively.
Cagrilintide is an investigational novel long-acting acylated amylin analogue, acts as nonselective amylin receptors (AMYR) and calcitonin G protein-coupled receptor (CTR) agonist. Cagrilintide induces significant weight loss and reduces food intake. Cagrilintide has the potential for the research of obesity.
体内研究：
Cagrilintide (compound 23) (0.1, 1, 3, 10, 30 nmol/kg; s.c.) reduces food intake in the rat.Cagrilintide (10 nmol/kg; i.v. or s.c.) shows good pharmacokinetic parameters.Animal Model:12 weeks, 400 g Sprague Dawley male rats
Dosage:0.1, 1, 3, 10, 30 nmol/kg
Administration:S.c.; once for 80 h
Result:Reduced food intake in the rat for several days at doses in the range of 1-10 nmol/kg.
Animal Model:12 weeks, 400 g Sprague Dawley male rats
Dosage:10 nmol/kg
Administration:I.v.; s.c.
Result:Showed good pharmacokinetic parameters with T1/2 of 20±2, 27±3 h for i.v. and s.c., respectively.
产品资料
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