产品
编 号：F744843
分子式：C32H27Cl2F4N3O6
分子量：696.47
分子式：C32H27Cl2F4N3O6
分子量：696.47
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 1410737-35-7
产品详情
生物活性：
MI-1061 TFA is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM). MI-1061 TFA potently activates p53 and induces apoptosis in the SJSA-1 xenograft tumor tissue in mice. Anti-tumor activity.
体内研究：
MI-1061 (100 mg/kg; p.o.; daily for 14 days) is capable of achieving tumor regression in the SJSA-1 xenograft tumor model in mice.Animal Model:SCID mice bearing SJSA-1 osteosarcoma xenografts
Dosage:100 mg/kg
Administration:P.o.; daily for 14 days
Result:Demonstrated strong antitumor activity and achieved significant tumor regression.
体外研究：
MI-1061 achieves IC50=100 and 250 nM in the SJSA-1 and HCT-116 p53+/+ cell lines, respectively, and has IC50>10000 nM in the p53 knockout cell line HCT-116 p53–/–cell line.
MI-1061 TFA is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM). MI-1061 TFA potently activates p53 and induces apoptosis in the SJSA-1 xenograft tumor tissue in mice. Anti-tumor activity.
体内研究：
MI-1061 (100 mg/kg; p.o.; daily for 14 days) is capable of achieving tumor regression in the SJSA-1 xenograft tumor model in mice.Animal Model:SCID mice bearing SJSA-1 osteosarcoma xenografts
Dosage:100 mg/kg
Administration:P.o.; daily for 14 days
Result:Demonstrated strong antitumor activity and achieved significant tumor regression.
体外研究：
MI-1061 achieves IC50=100 and 250 nM in the SJSA-1 and HCT-116 p53+/+ cell lines, respectively, and has IC50>10000 nM in the p53 knockout cell line HCT-116 p53–/–cell line.
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