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编 号：F744811
分子量：7344
分子量：7344
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CAS No: 1403787-62-1
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生物活性：
Bepirovirsen is an antisense oligonucleotide targeting all HBV messenger RNAs. Bepirovirsen leads to reductions in HBV-derived RNAs, HBV DNA and viral proteins. Bepirovirsen can be used for the research of chronic HBV infection. Bepirovirsen binding site sequence (GCACTTCGCTTCACCTCTGC).
体内研究：
Bepirovirsen (22-50 mg/kg/周; 皮下注射，第 1 周每周两次，第 2-4 周每周一次) 可减少 HBV 转基因小鼠的肝脏 HBV RNA 和 DNA。Animal Model:Male HBV transgenic mice (Tg[HBV 1.3 genome]Chi32 against C57BL/6 background) aged 7-12 weeks and weight 18-25 g.
Dosage:22, 50 mg/kg/week
Administration:Injected subcutaneously twice weekly for week 1 and once weekly for weeks 2-4
Result:Dose-dependently reduced hepaticlevels of HBV DNA and HBV RNA in HBV transgenic mice.Reduced levels of serum HBV DNA, serum HBsAg and serum HBeAg.
体外研究：
Bepirovirsen（16-250 nM；16 小时）可减少 HepG2.2.15 细胞中的乙型肝炎病毒 (HBV) RNA、DNA 和病毒蛋白。
Bepirovirsen is an antisense oligonucleotide targeting all HBV messenger RNAs. Bepirovirsen leads to reductions in HBV-derived RNAs, HBV DNA and viral proteins. Bepirovirsen can be used for the research of chronic HBV infection. Bepirovirsen binding site sequence (GCACTTCGCTTCACCTCTGC).
体内研究：
Bepirovirsen (22-50 mg/kg/周; 皮下注射，第 1 周每周两次，第 2-4 周每周一次) 可减少 HBV 转基因小鼠的肝脏 HBV RNA 和 DNA。Animal Model:Male HBV transgenic mice (Tg[HBV 1.3 genome]Chi32 against C57BL/6 background) aged 7-12 weeks and weight 18-25 g.
Dosage:22, 50 mg/kg/week
Administration:Injected subcutaneously twice weekly for week 1 and once weekly for weeks 2-4
Result:Dose-dependently reduced hepaticlevels of HBV DNA and HBV RNA in HBV transgenic mice.Reduced levels of serum HBV DNA, serum HBsAg and serum HBeAg.
体外研究：
Bepirovirsen（16-250 nM；16 小时）可减少 HepG2.2.15 细胞中的乙型肝炎病毒 (HBV) RNA、DNA 和病毒蛋白。
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