产品
编 号：F744782
分子式：C21H33N7O5
分子量：463.53
分子式：C21H33N7O5
分子量：463.53
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结构图
CAS No: 1402453-15-9
产品详情
生物活性：
ATIC-IN-1(compound 14) is an inhibitor targeting to Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC) dimerization with a Ki value of 685 nM. ATIC dimerization is crucial for its aminoimidazole carboxamide ribonucleotide (AICAR) transformylase activity. ATIC-IN-1 exhibits anti-tumor activity via reduction in cell numbers and cell division rates.
体外研究：
ATIC-IN-1（10 μM, 50 μM）是一种特异性抑制剂，在 1 mg/mL 和 10 mg/mL BSA 存在或不存在时，表现出非特异性聚集机制。ATIC-IN-1（100-500 μM；48 h）抑制 MCF-7 细胞的增殖。ATIC-IN-1（250 μM；24-72 小时）导致分裂减少而不是导致细胞死亡增加。
ATIC-IN-1(compound 14) is an inhibitor targeting to Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC) dimerization with a Ki value of 685 nM. ATIC dimerization is crucial for its aminoimidazole carboxamide ribonucleotide (AICAR) transformylase activity. ATIC-IN-1 exhibits anti-tumor activity via reduction in cell numbers and cell division rates.
体外研究：
ATIC-IN-1（10 μM, 50 μM）是一种特异性抑制剂，在 1 mg/mL 和 10 mg/mL BSA 存在或不存在时，表现出非特异性聚集机制。ATIC-IN-1（100-500 μM；48 h）抑制 MCF-7 细胞的增殖。ATIC-IN-1（250 μM；24-72 小时）导致分裂减少而不是导致细胞死亡增加。
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