产品
编 号：F744749
分子式：C24H26N2O2
分子量：374.48
分子式：C24H26N2O2
分子量：374.48
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 1398695-47-0
产品详情
生物活性：
GSK2646264 (Compound 44) is a potent and selective spleen tyrosine kinase (SYK) inhibitor with a pIC50 of 7.1. GSK2646264 also inhibits other kinases with pIC50 values of 5.4, 5.4, 5.3, 5, 4.5, <4.6 and <4.3 against LCK, LRRK2, GSK3β, JAK2, VEGFR2, Aurora B and Aurora A, respectively. GSK2646264 is penetrable into the epidermis and dermis of the skin.
体外研究：
GSK2646264 (0.01-10 μM; 1 h) significantly inhibits anti‐IgE (but not C5a)‐induced histamine release from skin mast cells in a concentration‐dependent manner. The IC50 is 0.7 μM and the IC90 is 6.8 μM.GSK2646264 cream (0.5, 1, and 3% [wt/wt]; 1 cm2; 4 and 24 h) inhibits anti‐IgE‐induced histamine release from mast cells in ex vivo human skin.
GSK2646264 (Compound 44) is a potent and selective spleen tyrosine kinase (SYK) inhibitor with a pIC50 of 7.1. GSK2646264 also inhibits other kinases with pIC50 values of 5.4, 5.4, 5.3, 5, 4.5, <4.6 and <4.3 against LCK, LRRK2, GSK3β, JAK2, VEGFR2, Aurora B and Aurora A, respectively. GSK2646264 is penetrable into the epidermis and dermis of the skin.
体外研究：
GSK2646264 (0.01-10 μM; 1 h) significantly inhibits anti‐IgE (but not C5a)‐induced histamine release from skin mast cells in a concentration‐dependent manner. The IC50 is 0.7 μM and the IC90 is 6.8 μM.GSK2646264 cream (0.5, 1, and 3% [wt/wt]; 1 cm2; 4 and 24 h) inhibits anti‐IgE‐induced histamine release from mast cells in ex vivo human skin.
产品资料
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