产品
编 号：F744746
分子式：C19H12FN3O2S
分子量：365.38
分子式：C19H12FN3O2S
分子量：365.38
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 1398496-82-6
产品详情
生物活性：
Afizagabar (S44819) is a first-in-class, competitive, and selective antagonist at the GABA-binding site of the α5-GABAAR, with an IC50 of 585 nM for α5β2γ2 and a Ki of 66 nM for α5β3γ2. Afizagabar enhances hippocampal synaptic plasticity and exhibits pro-cognitive efficacy.
体内研究：
Afizagabar (1 and 3 mg/kg; i.p.) significantly diminishes the marked increase in total errors induced by Scopolamine.Animal Model:Male Sprague Dawley (SPRD) rats (In the eight-arm radial maze)
Dosage:1 and 3 mg/kg
Administration:I.p.
Result:Significantly diminished the marked increase in total errors induced by Scopolamine.
体外研究：
Afizagabar (S44819) is a competitive α5-GABAAR antagonist (Kb=221 nM). Afizagabar selectively inhibits extrasynaptic α5-GABAARs of mouse CA1 pyramidal neurons.
Afizagabar (S44819) is a first-in-class, competitive, and selective antagonist at the GABA-binding site of the α5-GABAAR, with an IC50 of 585 nM for α5β2γ2 and a Ki of 66 nM for α5β3γ2. Afizagabar enhances hippocampal synaptic plasticity and exhibits pro-cognitive efficacy.
体内研究：
Afizagabar (1 and 3 mg/kg; i.p.) significantly diminishes the marked increase in total errors induced by Scopolamine.Animal Model:Male Sprague Dawley (SPRD) rats (In the eight-arm radial maze)
Dosage:1 and 3 mg/kg
Administration:I.p.
Result:Significantly diminished the marked increase in total errors induced by Scopolamine.
体外研究：
Afizagabar (S44819) is a competitive α5-GABAAR antagonist (Kb=221 nM). Afizagabar selectively inhibits extrasynaptic α5-GABAARs of mouse CA1 pyramidal neurons.
产品资料
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