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编 号：F744699
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CAS No: 1393659-46-5
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生物活性：
Diridavumab is a monoclonal anti-HA stalk antibody. Diridavumab stabilizes the prefusion HA structure and prevents pH-dependent fusion of cellular and viral membranes in endosomes. Diridavumab can be used in research of H2 influenza virus.
体内研究：
Diridavumab (CR6261; 1.7-15 mg/kg; i.p.; 携带 H2 流感病毒的 BALB/c 小鼠) 以剂量依赖性方式保护小鼠免受致命的 H2 流感病毒的侵害。Animal Model:BALB/c mice with H2 influenza virus
Dosage:1.7, 5, or 15 mg/kg
Administration:Intraperitoneal injection
Result:Prevented mortality and decreased the percent weight loss.Decreased viral load, altered antigen distribution, and reduced the severity of airway inflammation.
体外研究：
Diridavumab (CR6261; 500 μg/mL) 分别以 39.4 μg/mL 和 176.8 μg/mL 的浓度中和 AA60 和 Sw06。
Diridavumab is a monoclonal anti-HA stalk antibody. Diridavumab stabilizes the prefusion HA structure and prevents pH-dependent fusion of cellular and viral membranes in endosomes. Diridavumab can be used in research of H2 influenza virus.
体内研究：
Diridavumab (CR6261; 1.7-15 mg/kg; i.p.; 携带 H2 流感病毒的 BALB/c 小鼠) 以剂量依赖性方式保护小鼠免受致命的 H2 流感病毒的侵害。Animal Model:BALB/c mice with H2 influenza virus
Dosage:1.7, 5, or 15 mg/kg
Administration:Intraperitoneal injection
Result:Prevented mortality and decreased the percent weight loss.Decreased viral load, altered antigen distribution, and reduced the severity of airway inflammation.
体外研究：
Diridavumab (CR6261; 500 μg/mL) 分别以 39.4 μg/mL 和 176.8 μg/mL 的浓度中和 AA60 和 Sw06。
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