产品
编 号：F744681
分子式：C23H27N7O2
分子量：433.51
分子式：C23H27N7O2
分子量：433.51
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CAS No: 1392421-71-4
产品详情
生物活性：
PI3K/mTOR Inhibitor-9 (Compound 1) is a potent mTOR and PI3K inhibitor with IC50 values of 38 nM, 6.6 μM, 6.6 μM and 0.8 μM against mTOR (phospho-S6 cellular assay), PI3Kα, PI3Kγ and PI3Kδ, respectively.
体外研究：
PI3K/mTOR Inhibitor-9 (Compound 1) shows good selectivity over the related kinases PI3Kα, β and γ, although with lower selectivity over PI3Kδ.PI3K/mTOR Inhibitor-9 inhibits CYP2D6 (IC50 = 1.98 μM) and shows time-dependent inhibition (TDI) of CYP3A4 (rate of enzyme inhibition, kobs = 0.080 /min).PI3K/mTOR Inhibitor-9 shows good permeability with no sign of P-gp efflux (B-A/A-B: 0.95) .
PI3K/mTOR Inhibitor-9 (Compound 1) is a potent mTOR and PI3K inhibitor with IC50 values of 38 nM, 6.6 μM, 6.6 μM and 0.8 μM against mTOR (phospho-S6 cellular assay), PI3Kα, PI3Kγ and PI3Kδ, respectively.
体外研究：
PI3K/mTOR Inhibitor-9 (Compound 1) shows good selectivity over the related kinases PI3Kα, β and γ, although with lower selectivity over PI3Kδ.PI3K/mTOR Inhibitor-9 inhibits CYP2D6 (IC50 = 1.98 μM) and shows time-dependent inhibition (TDI) of CYP3A4 (rate of enzyme inhibition, kobs = 0.080 /min).PI3K/mTOR Inhibitor-9 shows good permeability with no sign of P-gp efflux (B-A/A-B: 0.95) .
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