产品
编 号：F744541
分子式：C21H25NO3
分子量：339.43
分子式：C21H25NO3
分子量：339.43
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 1377897-01-2
产品详情
生物活性：
ERD03 is a potent disruptor of the EXOSC3-RNA interaction, with a?Kd?of 17±7?μM?. ERD03 induces PCH1B-like phenotype in zebrafish embryo and can be used for neurological disorder?disease research.
体外研究：
ERD03 inhibits the binding of ?G-rich RNA and EXOSC3?with ~18% inhibition at 50 μM.ERD03 (50 μM; 5 days) causes significant spinal curvature and recapitulates PCH1B phenotype in development in zebrafish embryos.ERD03 (50 μM) induces a ~6-fold upregulation of ataxin1b mRNA and results in a minor accumulation of ataxin1a mRNA in embryos. ERD03 induces an atrophy of the zebrafish cerebellum and results in zebrafish cerebella half the size of control brains in DMSO.
ERD03 is a potent disruptor of the EXOSC3-RNA interaction, with a?Kd?of 17±7?μM?. ERD03 induces PCH1B-like phenotype in zebrafish embryo and can be used for neurological disorder?disease research.
体外研究：
ERD03 inhibits the binding of ?G-rich RNA and EXOSC3?with ~18% inhibition at 50 μM.ERD03 (50 μM; 5 days) causes significant spinal curvature and recapitulates PCH1B phenotype in development in zebrafish embryos.ERD03 (50 μM) induces a ~6-fold upregulation of ataxin1b mRNA and results in a minor accumulation of ataxin1a mRNA in embryos. ERD03 induces an atrophy of the zebrafish cerebellum and results in zebrafish cerebella half the size of control brains in DMSO.
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