产品
编 号：F074230
分子式：H2Na6O40W12
分子量：2986.01
分子式：H2Na6O40W12
分子量：2986.01
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
184
In-stock
10mg
295
In-stock
25mg
560
In-stock
结构图
CAS No: 12141-67-2
产品详情
生物活性：
Sodium metatungstate (Sodium polyoxotungstate) is a NTPDase inhibitor, with Ki values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1 (CD39), NTPDase 3 and NTPDase 2 respectively. Sodium metatungstate has anti-inflammatory and anti-cancer effect. Sodium metatungstate inhibits ATP breakdown but also blocks central synaptic transmission.
体内研究：
Sodium metatungstate (5 mg/kg，腹腔注射，单次剂量) 在 CD39 基因敲除小鼠的腹膜和全身血流中显示出不同的细胞因子/趋化因子反应。Sodium metatungstate (5 mg/kg，腹腔注射，一天一次，从第 0 天至第 4 天、第 7 天至第 11 天、第14 天至第 18 天) 联合抗 CD73 抗体和 AZD4635(HY-101980) 可降低多发性骨髓瘤 (MM) 小鼠的肿瘤负荷。Animal Model:Multiple myeloma (MM) mice developed by 3 weeks of injection of 5t33MM cells
Dosage:5 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Had significantly lower spleen weights, fewer tumor cells in the spleen as well as significantly lower monoclonal immunoglobulin component level in circulation.
体外研究：
Sodium metatungstate (100 μM, 15 min) 在巨噬细胞中抑制 ATP 诱导的阴离子染料摄取和大通道。Sodium metatungstate (100 μM, 8 h) 抑制 ATP 诱导的 P2X7 相关巨噬细胞焦亡。Sodium metatungstate (100 μM, 8-24 h) 对巨噬细胞有很强的抗炎作用。
Sodium metatungstate (Sodium polyoxotungstate) is a NTPDase inhibitor, with Ki values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1 (CD39), NTPDase 3 and NTPDase 2 respectively. Sodium metatungstate has anti-inflammatory and anti-cancer effect. Sodium metatungstate inhibits ATP breakdown but also blocks central synaptic transmission.
体内研究：
Sodium metatungstate (5 mg/kg，腹腔注射，单次剂量) 在 CD39 基因敲除小鼠的腹膜和全身血流中显示出不同的细胞因子/趋化因子反应。Sodium metatungstate (5 mg/kg，腹腔注射，一天一次，从第 0 天至第 4 天、第 7 天至第 11 天、第14 天至第 18 天) 联合抗 CD73 抗体和 AZD4635(HY-101980) 可降低多发性骨髓瘤 (MM) 小鼠的肿瘤负荷。Animal Model:Multiple myeloma (MM) mice developed by 3 weeks of injection of 5t33MM cells
Dosage:5 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Had significantly lower spleen weights, fewer tumor cells in the spleen as well as significantly lower monoclonal immunoglobulin component level in circulation.
体外研究：
Sodium metatungstate (100 μM, 15 min) 在巨噬细胞中抑制 ATP 诱导的阴离子染料摄取和大通道。Sodium metatungstate (100 μM, 8 h) 抑制 ATP 诱导的 P2X7 相关巨噬细胞焦亡。Sodium metatungstate (100 μM, 8-24 h) 对巨噬细胞有很强的抗炎作用。
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