产品
编 号：F744488
分子式：C16H24N6O4
分子量：364.4
分子式：C16H24N6O4
分子量：364.4
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规格
价格
是否有货
10mM*1mL in DMSO
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 1372206-64-8
产品详情
生物活性：
THX-B is a potent and non-peptidic p75NTR (neurotrophin receptor p75) antagonist. THX-B can be used in the research of diabetic kidney disease, neurodegenerative and inflammatory disorders.
体内研究：
THX-B (50 μg in 125 μL PBS, i.p. weekly for 4 weeks) improves bladder function in a mouse model of diabetic voiding dysfunction. THX-B (2?μL of 2?μg/μL, IVT injection, a single dose) elicits a neuroprotective effect on photoreceptor cells in P17 rd10 mice. THX-B (40 μg in 20 μL, IVT injection) resolves the inflammatory, vascular, and neurodegenerative phases of the retinal pathology. Animal Model:Mouse model of diabetic voiding dysfunction
Dosage:50 μg in 125 μL PBS
Administration:Intraperitoneal injection (i.p.)
Result:Prevented bladder weight increase, which was 18% (95% CI 3%, 32%) and 37% (95% CI 14%, 60%) lower after 2 and 4 weeks of treatment.
Animal Model:P17 rd10 mice
Dosage:2?μL of 2?μg/μL, single dose
Administration:Intravitreal (IVT) injected in one eye
Result:Increased the number of photoreceptor rows as well as the ONL/INL ratio.Decreased the total number of microglial cells in the treated retinas, as well as some of the inflammatory signs, such as GFAP, α2M and the proinflammatory cytokines IL-1β and TNFα.
体外研究：
THX-B (10 μM, 4 days) decreases proliferation of myoblasts.THX-B (10 μM, 1 h) inhibits NGF-induced phosphorylation of ERK1/2 in C2C12 myoblasts.THX-B (20 μM, 24 h) decreases photoreceptor cell death and reactive gliosis in cultured rd10 retinas.
THX-B is a potent and non-peptidic p75NTR (neurotrophin receptor p75) antagonist. THX-B can be used in the research of diabetic kidney disease, neurodegenerative and inflammatory disorders.
体内研究：
THX-B (50 μg in 125 μL PBS, i.p. weekly for 4 weeks) improves bladder function in a mouse model of diabetic voiding dysfunction. THX-B (2?μL of 2?μg/μL, IVT injection, a single dose) elicits a neuroprotective effect on photoreceptor cells in P17 rd10 mice. THX-B (40 μg in 20 μL, IVT injection) resolves the inflammatory, vascular, and neurodegenerative phases of the retinal pathology. Animal Model:Mouse model of diabetic voiding dysfunction
Dosage:50 μg in 125 μL PBS
Administration:Intraperitoneal injection (i.p.)
Result:Prevented bladder weight increase, which was 18% (95% CI 3%, 32%) and 37% (95% CI 14%, 60%) lower after 2 and 4 weeks of treatment.
Animal Model:P17 rd10 mice
Dosage:2?μL of 2?μg/μL, single dose
Administration:Intravitreal (IVT) injected in one eye
Result:Increased the number of photoreceptor rows as well as the ONL/INL ratio.Decreased the total number of microglial cells in the treated retinas, as well as some of the inflammatory signs, such as GFAP, α2M and the proinflammatory cytokines IL-1β and TNFα.
体外研究：
THX-B (10 μM, 4 days) decreases proliferation of myoblasts.THX-B (10 μM, 1 h) inhibits NGF-induced phosphorylation of ERK1/2 in C2C12 myoblasts.THX-B (20 μM, 24 h) decreases photoreceptor cell death and reactive gliosis in cultured rd10 retinas.
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