产品
编 号：F744391
分子式：C18H16N6
分子量：316.36
分子式：C18H16N6
分子量：316.36
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CAS No: 1360243-08-8
产品详情
生物活性：
LabMol-301 inhibits both NS5 RdRp and NS2B-NS3pro activity (IC50: 0.8 and 7.4 μM, respectively). LabMol-301 has a cytoprotective effect and prevents Zika virus (ZIKV)-induced cell death.
体外研究：
LabMol-301 (20 μM) shows 99% inhibition rate of NS5 RdRp activity.LabMol-301 (10 μM) inhibits more than 80% of the NS2B-NS3pro protease activity.LabMol-301 interacts with ZIKV NS2B-NS3pro at the allosteric site relied on a highly hydrophobic complementarity between the molecule’s surfaces and the protein.LabMol-301 is able to protect GSC387 cell from cell death induced by ZIKV (EC50: 6.68 μM).
LabMol-301 inhibits both NS5 RdRp and NS2B-NS3pro activity (IC50: 0.8 and 7.4 μM, respectively). LabMol-301 has a cytoprotective effect and prevents Zika virus (ZIKV)-induced cell death.
体外研究：
LabMol-301 (20 μM) shows 99% inhibition rate of NS5 RdRp activity.LabMol-301 (10 μM) inhibits more than 80% of the NS2B-NS3pro protease activity.LabMol-301 interacts with ZIKV NS2B-NS3pro at the allosteric site relied on a highly hydrophobic complementarity between the molecule’s surfaces and the protein.LabMol-301 is able to protect GSC387 cell from cell death induced by ZIKV (EC50: 6.68 μM).
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