产品
编 号:F744285
分子式:C32H31ClN6O4
分子量:599.08
产品类型
结构图
CAS No: 1351941-69-9
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产品详情
生物活性:
Sacibertinib is a tyrosine kinase (Trk) inhibitor with EC50 value of 110 nM and 244 nM for EGFR-TK phosphorylation and HER2, respectively. Antineoplastic activity.
体外研究:
Sacibertinib has inhibitory activity against Sk-Br-3, SW620 cells with GI50s of 3.8 nM and 1.78 μM, and against CCRF-CEM/T, Fadu, BxPc-3 and AsPC-1 with IC50s of 5.6 μM, 101 nM, 337 nM and 1 μM, respectively.