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编 号：F744270
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1mg
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5mg
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CAS No: 1350624-75-7
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生物活性：
Margetuximab (MGAH22) is a chimeric anti-HER2 monoclonal antibody optimized Fc domain, with an EC50 value of 39.33 ng/mL. Margetuximab can be used for researching metastatic HER2-positive breast cancer.
体内研究：
Margetuximab (2-4 mg/kg; IP 5 or 6 times at weekly) can firstly and significantly reduces the tumor size at day 30 - 37 in mice model.Margetuximab (15-150 mg/kg; IV; 6 weekly) exhibits well tolerated in cynomolgus monkeys, decreases NK cells by an average of 51%, and induces IL-6 release.Margetuximab (50 mg/kg; IV; single dosage) exhibits favorable safety profile.Pharmacokinetic Parameters of Margetuximab in cynomolgus monkeys.Male, IV (50 mg/kg) Female, IV (50 mg/kg)
Cmax (mg/mL)1.62 ± 0.101.70 ± 0.14
AUC0-(mg·hour/mL)294.1 ± 53.2314.2 ± 31.3
T1/2β (days)9.3 ± 1.89.7 ± 1.1
Clearance (mL/hour)0.43 ± 0.070.40 ± 0.04
VSS (mL)132 ± 2127 ± 8
体外研究：
Margetuximab (MGAH22) enhances the antibody-dependent cell-mediated cytotoxicity activity of effector cells expressing the CD16A-158F variant.
Margetuximab (MGAH22) is a chimeric anti-HER2 monoclonal antibody optimized Fc domain, with an EC50 value of 39.33 ng/mL. Margetuximab can be used for researching metastatic HER2-positive breast cancer.
体内研究：
Margetuximab (2-4 mg/kg; IP 5 or 6 times at weekly) can firstly and significantly reduces the tumor size at day 30 - 37 in mice model.Margetuximab (15-150 mg/kg; IV; 6 weekly) exhibits well tolerated in cynomolgus monkeys, decreases NK cells by an average of 51%, and induces IL-6 release.Margetuximab (50 mg/kg; IV; single dosage) exhibits favorable safety profile.Pharmacokinetic Parameters of Margetuximab in cynomolgus monkeys.Male, IV (50 mg/kg) Female, IV (50 mg/kg)
Cmax (mg/mL)1.62 ± 0.101.70 ± 0.14
AUC0-(mg·hour/mL)294.1 ± 53.2314.2 ± 31.3
T1/2β (days)9.3 ± 1.89.7 ± 1.1
Clearance (mL/hour)0.43 ± 0.070.40 ± 0.04
VSS (mL)132 ± 2127 ± 8
体外研究：
Margetuximab (MGAH22) enhances the antibody-dependent cell-mediated cytotoxicity activity of effector cells expressing the CD16A-158F variant.
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