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编 号：F744227
分子式：C19H18N2O3
分子量：322.36
分子式：C19H18N2O3
分子量：322.36
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CAS No: 1345674-93-2
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生物活性：
Callophycin A, a red seaweed derived metabolite, possessing potent activity against Candida albicans with MIC of 62.5~250 mg/L. Callophycin A significantly reduces fungal burden of vaginal candidiasis induced mice, also decreases inflammatory response and immune molecules.
体内研究：
Callophycin A (1%; for 5 days) dramatically reduces CFU of Candida albicans; and significantly reduces the amount of IL-6, IL-12, IL-17 and IL-22 compared with disease control group.Animal Model:Female Swiss albino mice (infected with Candida albicans)
Dosage:1%
Administration:For 5 days
Result:Dramatically reduces CFU of Candida albicans from about 400 to 100/ml; and significantly (p < 0.001) reduces the amount of IL-6 (2.71 ± 0.09 to 1.83 ± 0.03 pg/μl), IL-12 (7.33 ± 0.15 to 6.13 ± 0.15 pg/μl), IL-17 (17.83 ± 0.21 to 13.70 ± 0.2 pg/μl) and IL-22 (5.33 ± 0.25 to 4.20 ± 0.26 pg/μl) compared with disease control group.
Callophycin A, a red seaweed derived metabolite, possessing potent activity against Candida albicans with MIC of 62.5~250 mg/L. Callophycin A significantly reduces fungal burden of vaginal candidiasis induced mice, also decreases inflammatory response and immune molecules.
体内研究：
Callophycin A (1%; for 5 days) dramatically reduces CFU of Candida albicans; and significantly reduces the amount of IL-6, IL-12, IL-17 and IL-22 compared with disease control group.Animal Model:Female Swiss albino mice (infected with Candida albicans)
Dosage:1%
Administration:For 5 days
Result:Dramatically reduces CFU of Candida albicans from about 400 to 100/ml; and significantly (p < 0.001) reduces the amount of IL-6 (2.71 ± 0.09 to 1.83 ± 0.03 pg/μl), IL-12 (7.33 ± 0.15 to 6.13 ± 0.15 pg/μl), IL-17 (17.83 ± 0.21 to 13.70 ± 0.2 pg/μl) and IL-22 (5.33 ± 0.25 to 4.20 ± 0.26 pg/μl) compared with disease control group.
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