产品
编 号：F744131
分子式：C17H18ClN3OS
分子量：347.86
分子式：C17H18ClN3OS
分子量：347.86
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CAS No: 1333636-58-0
产品详情
生物活性：
PqsR-IN-1 (Compound 18) is a potent PqsR (Pseudomonas aeruginosa quorum sensing transcriptional regulator) inhibitor. PqsR-IN-1 attenuates pyocyanin production and has very low cytotoxicity.
体外研究：
PqsR-IN-1 (Compound 18) inhibits pqs system with IC50 values of 313 ± 156.2 nM and 342 ± 39.4 nM against two different PA strains PAO1-L and PA14, respectively.PqsR-IN-1 significantly reduces pyocyanin production to 23% against a control of 0.1% DMSO at 3 × the IC50 value in P. aeruginosa strain PAO1-L. PqsR-IN-1 (0-100 μM, 16 h) shows no significant toxicity to A549 cells.
PqsR-IN-1 (Compound 18) is a potent PqsR (Pseudomonas aeruginosa quorum sensing transcriptional regulator) inhibitor. PqsR-IN-1 attenuates pyocyanin production and has very low cytotoxicity.
体外研究：
PqsR-IN-1 (Compound 18) inhibits pqs system with IC50 values of 313 ± 156.2 nM and 342 ± 39.4 nM against two different PA strains PAO1-L and PA14, respectively.PqsR-IN-1 significantly reduces pyocyanin production to 23% against a control of 0.1% DMSO at 3 × the IC50 value in P. aeruginosa strain PAO1-L. PqsR-IN-1 (0-100 μM, 16 h) shows no significant toxicity to A549 cells.
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