产品
编 号：F073729
分子式：C13H17N5O6
分子量：339.3
分子式：C13H17N5O6
分子量：339.3
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 121288-39-9
产品详情
生物活性：
Loxoribine (7-Allyl-8-oxoguanosine) is a guanosine analog with anti-viral and anti-tumor activities. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist.
体内研究：
Loxoribine (2 mg; s.c.or i.v.) activates murine natural killer (NK) cells in vivo.Animal Model:8-12 weeks male CBA/J mice
Dosage:2 mg
Administration:Subcutaneous or intravenous injection
Result:activates murine natural killer (NK) cells in vivo.
体外研究：
Loxoribine induces maturation of human monocyte-derived dendritic cells DCs and stimulates their Th-1- and Th-17-polarizing capability.Loxoribine (250 μM; 48 hours) stimulates maturation of MoDCs as shown by up-regulation of CD80, CD83, CD40, CD54 and CCR7.loxoribine activates cells of the innate immune system selectively via the Toll-like receptor (TLR) 7/MyD88-dependent signaling pathway.
Loxoribine (7-Allyl-8-oxoguanosine) is a guanosine analog with anti-viral and anti-tumor activities. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist.
体内研究：
Loxoribine (2 mg; s.c.or i.v.) activates murine natural killer (NK) cells in vivo.Animal Model:8-12 weeks male CBA/J mice
Dosage:2 mg
Administration:Subcutaneous or intravenous injection
Result:activates murine natural killer (NK) cells in vivo.
体外研究：
Loxoribine induces maturation of human monocyte-derived dendritic cells DCs and stimulates their Th-1- and Th-17-polarizing capability.Loxoribine (250 μM; 48 hours) stimulates maturation of MoDCs as shown by up-regulation of CD80, CD83, CD40, CD54 and CCR7.loxoribine activates cells of the innate immune system selectively via the Toll-like receptor (TLR) 7/MyD88-dependent signaling pathway.
产品资料
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